LIQUID CRYSTALLINE INVERTED LIPID PHASES ENCAPSULATING SIRNA ENHANCE LIPID NANOPARTICLE MEDIATED TRANSFECTION

Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection

Abstract Efficient cytosolic delivery of RNA molecules remains a formidable barrier for RNA therapeutic strategies.Lipid nanoparticles (LNPs) serve as state-of-the-art carriers that can deliver RNA molecules intracellularly, as exemplified by the recent implementation of several vaccines against SARS-CoV-2.Using a bottom-up rational design approach

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